Familial Kaposi's sarcoma: A cluster of five Israeli cases

A. Weissmann-Brenner, R. Friedman-Birnbaum, B. Brenner

Research output: Contribution to journalArticlepeer-review

Abstract

Aim: Familial cases of Kaposi's sarcoma (KS) are rare, and have all been described in patients with the classical variant of the disease. The predisposition of classical Kaposi's sarcoma among Jews is well known. We herein describe five families, all Jews, in which two members have Kaposi's sarcoma. To our knowledge, this has been the largest reported series of familial Kaposi's sarcoma. Patients and methods: The clinical course, management and response to therapy were described and compared with other published cases. Results: No similarity was found in any of the families in time and age of onset of the disease, or in the severity and course of the disease among the members of the same family. There was a high incidence of second neoplasms among these familial cases. Conclusions: We discuss the potential implications of second neoplasms based on our understanding of the pathogenesis of the disease, as well as the influence or predisposal of some genetic mechanisms to the development of Kaposi's sarcoma.

Original languageEnglish
Pages (from-to)125-128
Number of pages4
JournalClinical Oncology
Volume16
Issue number2
DOIs
StatePublished - Apr 2004
Externally publishedYes

Keywords

  • Familial Kaposi's sarcoma
  • Israel
  • Second neoplasms

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