Familial hypothyroidism with autosomal dominant inheritance

M. Mimouni*, A. Mimouni-Bloch, J. Schachter, M. Shohat

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

13 Scopus citations


Three generations of a family with clinical and subclinical hypothyroidism caused by thyroid stimulating hormone (TSH) unresponsiveness are described. Findings were low to normal serum thyroxine, raised serum TSH, and low radioiodine uptake; goitre was notably absent. This family is the first evidence of an autosomal dominant mode of transmission of TSH unresponsiveness and may enable identification of the precise defect by genetic linkage study.

Original languageEnglish
Pages (from-to)245-246
Number of pages2
JournalArchives of Disease in Childhood
Issue number3
StatePublished - 1996


  • Non-goitrous hypothyroidism
  • Thyroid stimulating hormone unresponsiveness


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