Hypertension accompanied by hyperkalemia was found incidentally in a 30 yr old patient and later in 3 additional members of 2 generations of his family; another member had hyperkalemia but was normotensive. During 20 yr of follow up, 500 mg chlorothiazide daily reduced hypertension and hyperkalemia to normal values. Renal and adrenal function were normal and there was no salt loss. The renal response to sodium sulfate and mannitol infusion was normal, as was the response to aldosterone administration. Angiotensin infusion increased endogenous aldosterone and antinatriuresis. Although the investigations have not established the mechanism in the pathogenesis of either the hyperkalemia or the hypertension, genetic considerations lead one to believe that these represent features of a single familial syndrome, rather than 2 unrelated coincidental diseases.
|State||Published - 1976|