Familial fragile site found at the cancer breakpoint (1)(q32) - Inducibility by distamycin A, concomitance with fragile (16)(q22)

Fiorella Shabtai, J. Hart, D. Klar, I. Halbrecht*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

A normal baby was cytogenetically examined immediately after birth for the possible presence of a fragile (16)(q22), which had been found in her mother and in her retarded sister with a 46,XX;46,XX,del(16)(q22) mosaic karyotype. Distamycin a was added to the cultures to enhance the fragile (16)(q22) expression. The response of the baby to the action of distamycin a in vitro was much greater than that of her family members. A fragile (16)(q22) was induced in many cells as well as a fragile (1)(q32), which was also found in her mother. This fragile site, which is known to be a cancer breakpoint, has not been reported so far either to be familial or to be inducible by distamycin A. The concomitance of fragile (1)(q32) with fragile (16)(q22) and their possible significance are considered.

Original languageEnglish
Pages (from-to)232-234
Number of pages3
JournalHuman Genetics
Volume73
Issue number3
DOIs
StatePublished - Jul 1986

Fingerprint

Dive into the research topics of 'Familial fragile site found at the cancer breakpoint (1)(q32) - Inducibility by distamycin A, concomitance with fragile (16)(q22)'. Together they form a unique fingerprint.

Cite this