Familial Down's syndrome

J. Chemke, B. Goldman

Research output: Contribution to journalArticlepeer-review


A family is reported in which the same mother conceived two children with trisomy 21. The pregnancy with the second affected child was interrupted after diagnostic amniocentesis. Maternal chromosome analysis was normal. This family and those previously reported suggest that there is an increased recurrence risk of trisomy 21 after the birth of an affected individual, possibly caused by a genetic tendency for nondisjunction. After the birth of a child with Down's syndrome, amniocentesis and chromosome analysis of cultured amniotic fluid cells is indicated in each further pregnancy, irrespective of maternal age.

Original languageEnglish
Pages (from-to)189-193
Number of pages5
JournalJournal de Genetique Humaine
Issue number3
StatePublished - 1977
Externally publishedYes


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