TY - JOUR
T1 - Familial clustering of malignant germ cell tumors and Langerhans' histiocytosis
AU - Mandel, Mathida
AU - Toren, Amos
AU - Kende, George
AU - Neuman, Yoram
AU - Kenet, Gilli
AU - Rechavi, Gideon
PY - 1994/4/1
Y1 - 1994/4/1
N2 - Three sisters in a family with seven children whose grandmother had an ovarian embryonal carcinoma experienced development of malignant and a malignant–like situation in childhood. Two were diagnosed as having malignant germ cell tumors of the ovary, and the third was found to have Langerhans' histiocytosis. The two girls with germ cell tumor shared an identical human leukocyte antigen, whereas the sister with histiocytosis shared one identical haplotype with them. All three children have been treated successfully with chemotherapy and are doing well off of treatment.
AB - Three sisters in a family with seven children whose grandmother had an ovarian embryonal carcinoma experienced development of malignant and a malignant–like situation in childhood. Two were diagnosed as having malignant germ cell tumors of the ovary, and the third was found to have Langerhans' histiocytosis. The two girls with germ cell tumor shared an identical human leukocyte antigen, whereas the sister with histiocytosis shared one identical haplotype with them. All three children have been treated successfully with chemotherapy and are doing well off of treatment.
KW - Langerhans' histiocytosis
KW - family cancer syndrome
KW - germ cell tumor
KW - human lymphocyte antigen
UR - http://www.scopus.com/inward/record.url?scp=0028206686&partnerID=8YFLogxK
U2 - 10.1002/1097-0142(19940401)73:7<1980::AID-CNCR2820730732>3.0.CO;2-9
DO - 10.1002/1097-0142(19940401)73:7<1980::AID-CNCR2820730732>3.0.CO;2-9
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AN - SCOPUS:0028206686
SN - 0008-543X
VL - 73
SP - 1980
EP - 1983
JO - Cancer
JF - Cancer
IS - 7
ER -
