Failure to replicate an association between the catechol-O-methyltransferase polymorphism and attention deficit hyperactivity disorder in a second, independently recruited Israeli cohort

Iris Manor, Moshe Kotler, Yonathan Sever, Jacques Eisenberg, Hagit Cohen, Richard P. Ebstein*, Samuel Tyano

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

41 Scopus citations


Attention deficit hyperactivity disorder (ADHD) is a developmental syndrome expressed along three domains: inattention, hyperactive-impulsive, and combined type. Both environmental and genetic factors contribute to the etiology of this complex disease. We previously reported an association in 48 ADHD triads (both parents and proband) between the catechol-O-methyl-transferase (COMT) polymorphism (especially the high enzyme activity val allele) and the Diagnostic and Statistical Manual of Mental Disorders (DSM IV) combined category (excluding inattention) of ADHD (however, see erratum, Am. J. Med. Genet. [Neuropsychiatr. Genet.] 96:000). In the current report, we attempted to replicate this finding in an independently recruited group of 70 nuclear families using the haplotype relative risk design. In the current investigation, no evidence for association of the COMT polymorphism and ADHD (or any of the DSM IV subtypes) was observed in either the current cohort or the expanded cohort of 118 Israeli triads. (C) 2000 Wiley-Liss, Inc.

Original languageEnglish
Pages (from-to)858-860
Number of pages3
JournalAmerican Journal of Medical Genetics, Part B: Neuropsychiatric Genetics
Issue number6
StatePublished - 4 Dec 2000
Externally publishedYes


  • Association
  • Attention deficit hyperactivity disorder (ADHD)
  • Catechol-O-methyltransferase (COMT)
  • Complex genetic disease
  • Haplotype relative risk
  • Polymorphism

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