Failure of quality control measures to prevent reporting of false resistance to imipenem, resulting in a pseudo-outbreak of imipenem-resistant Pseudomonas aeruginosa

Yehuda Carmeli, Karen Eichelberger, Don Soja, Joanna Dakos, Lata Venkataraman, Paola DeGirolami, Matthew Samore

Research output: Contribution to journalArticlepeer-review

Abstract

False results showing an outbreak of Pseudomonas aeruginosa with resistance to imipenem were traced to a defective lot of microdilution MIC testing panels. These panels contained two- to threefold lower concentrations of imipenem than expected and resulted in artifactual two- to fourfold increases in MICs of imipenem. The quality-control MIC results for Pseudomonas aeruginosa ATCC 27853 were 4 μg/ml, the highest value within the range recommended by the National Committee for Clinical Laboratory Standards. We recommend that this value be considered out of the quality- control range.

Original languageEnglish
Pages (from-to)595-597
Number of pages3
JournalJournal of Clinical Microbiology
Volume36
Issue number2
DOIs
StatePublished - Feb 1998
Externally publishedYes

Fingerprint

Dive into the research topics of 'Failure of quality control measures to prevent reporting of false resistance to imipenem, resulting in a pseudo-outbreak of imipenem-resistant Pseudomonas aeruginosa'. Together they form a unique fingerprint.

Cite this