TY - JOUR
T1 - Factors associated with improved glycemic control following continuous subcutaneous insulin infusion therapy in patients with type 2 diabetes uncontrolled with bolus-basal insulin regimens
T2 - An analysis from the OpT2mise randomized trial
AU - Metzger, Muriel
AU - Castañeda, Javier
AU - Reznik, Yves
AU - Giorgino, Francesco
AU - Conget, Ignacio
AU - Aronson, Ronnie
AU - de Portu, Simona
AU - Runzis, Sarah
AU - Lee, Scott W.
AU - Cohen, Ohad
N1 - Publisher Copyright:
© 2017 John Wiley & Sons Ltd
PY - 2017/10
Y1 - 2017/10
N2 - This analysis investigated factors associated with the decrease in HbA1c in patients receiving continuous subcutaneous insulin infusion (CSII) in the OpT2mise randomized trial. In this study, patients with type 2 diabetes and HbA1c >8% following multiple daily injections (MDI) optimization were randomized to receive CSII (n = 168) or MDI (n = 163) for 6 months. Patient-related and treatment-related factors associated with decreased HbA1c in the CSII arm were identified by univariate and multivariate analyses. CSII produced a significantly greater reduction in HbA1c than MDI, and the treatment difference increased with baseline HbA1c. In the CSII arm, the only factors significantly associated with decreased HbA1c were higher baseline HbA1c (P <.001), geographical region (P <.001), higher educational level (P =.012), higher total cholesterol level (P =.002), lower variability of baseline glucose values on continuous glucose monitoring (P <.001) and the decrease in average fasting self-monitored blood glucose at 6 months (P <.001). These findings suggest that CSII offers an option to improve glycemic control in a broad range of patients with type 2 diabetes in whom control cannot be achieved with MDI. OpT2mise ClinicalTrials.gov number: NCT01182493 (https://clinicaltrials.gov/).
AB - This analysis investigated factors associated with the decrease in HbA1c in patients receiving continuous subcutaneous insulin infusion (CSII) in the OpT2mise randomized trial. In this study, patients with type 2 diabetes and HbA1c >8% following multiple daily injections (MDI) optimization were randomized to receive CSII (n = 168) or MDI (n = 163) for 6 months. Patient-related and treatment-related factors associated with decreased HbA1c in the CSII arm were identified by univariate and multivariate analyses. CSII produced a significantly greater reduction in HbA1c than MDI, and the treatment difference increased with baseline HbA1c. In the CSII arm, the only factors significantly associated with decreased HbA1c were higher baseline HbA1c (P <.001), geographical region (P <.001), higher educational level (P =.012), higher total cholesterol level (P =.002), lower variability of baseline glucose values on continuous glucose monitoring (P <.001) and the decrease in average fasting self-monitored blood glucose at 6 months (P <.001). These findings suggest that CSII offers an option to improve glycemic control in a broad range of patients with type 2 diabetes in whom control cannot be achieved with MDI. OpT2mise ClinicalTrials.gov number: NCT01182493 (https://clinicaltrials.gov/).
KW - blood glucose self-monitoring
KW - glycated hemoglobin
KW - insulin infusion systems
KW - insulin therapy
KW - multiple daily injections
KW - type 2 diabetes mellitus
UR - http://www.scopus.com/inward/record.url?scp=85026216876&partnerID=8YFLogxK
U2 - 10.1111/dom.12960
DO - 10.1111/dom.12960
M3 - ???researchoutput.researchoutputtypes.contributiontojournal.article???
C2 - 28374511
AN - SCOPUS:85026216876
SN - 1462-8902
VL - 19
SP - 1490
EP - 1494
JO - Diabetes, Obesity and Metabolism
JF - Diabetes, Obesity and Metabolism
IS - 10
ER -