Factors associated with diabetes-specific health-related quality of life in youth with type 1 diabetes: The global teens study

Barbara J. Anderson*, Lori M. Laffel, Catherine Domenger, Thomas Danne, Moshe Phillip, Carmen Mazza, Ragnar Hanas, Sheridan Waldron, Roy W. Beck, Francoise Calvi-Gries, Chantal Mathieu

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

OBJECTIVE Our objective was to characterize diabetes-specific health-related quality of life (D-HRQOL) in a global sample of youth and young adults with type 1 diabetes (T1D) and to identify the main factors associated with quality of life. RESEARCH DESIGN AND METHODS The TEENs study was an international, cross-sectional study of youth, 8-25 years of age, with T1D. Participants (N= 5,887)were seen in clinical sites in 20 countries across 5 continents enrolled for 3 predetermined age groups: 8-12, 13-18, and 19-25 years of age. To assess D-HRQOL, participants completed the PedsQL DiabetesModule 3.0 and were interviewed about family-related factors. Specifics about treatment regimen and self-management behaviors were collected from medical records. RESULTS Across all age groups, females reported significantly lower D-HRQOL than didmales. The 19-25-year age group reported the lowest D-HRQOL. Multivariate linear regression analyses revealed that D-HRQOL was significantly related to HbA1c; the lower the HbA1c, the better the D-HRQOL. Three diabetes-management behaviors were significantly related to better D-HRQOL: advanced methods used to measure food intake;more frequent daily blood glucose monitoring; and more days per week that youth had 30 min of physical activity. CONCLUSIONS In all three age groups, the lower the HbA1c, the better the D-HRQOL, underscoring the strong association between better D-HRQOL and optimal glycemic control in a global sample of youth and young adults. Three diabetes-management behaviors were also related to optimal glycemic control, which represent potentially modifiable factors for clinical interventions to improve D-HRQOL as well as glycemic control.

Original languageEnglish
Pages (from-to)1002-1009
Number of pages8
JournalDiabetes Care
Volume40
Issue number8
DOIs
StatePublished - 1 Aug 2017
Externally publishedYes

Funding

FundersFunder number
Sanofi Diabetes
National Institutes of Health
National Institute of Diabetes and Digestive and Kidney DiseasesP30DK036836
Sanofi
Leona M. and Harry B. Helmsley Charitable Trust
Juvenile Diabetes Research Foundation United States of America

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