Factors affecting rise in the incidence of infiltrating lobular carcinoma of the breast

Bar Chikman, Ron Lavy, Tima Davidson, Ilan Wassermann, Judith Sandbank, Nava Siegelmann-Danieli, Ariel Halevy*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


Background: Infiltrating ductal carcinoma and infiltrating lobular carcinoma account for more than 90% of all invasive breast cancer histological types. The rate of ILC is reported to be increasing steadily in the United States and Europe. Objectives: To describe the trend in the incidence of ILC in a large cohort of patients who underwent surgery in a single institution over an 18 year period. Methods: Our comprehensive database of 2175 consecutive patients with invasive breast cancer diagnosed during the period 1992-2009 served for the analysis. Several potential factors associated with lobular carcinoma as compared with ductal carcinoma were evaluated. Results: During this period, a 2.4-fold increase in the incidence of pure ILC was noted, from 4.6% in the years 1992-1994 to 10.9% in 2004-2006, followed by a modest decrease to 8.7% in 2007-2009. A significant association of lobular malignancies with external hormonal use was noted, including hormone replacement therapy exposure in patients diagnosed at age 50-64, and ovarian overstimulation during in vitro fertilization in those diagnosed at age 50 or less. Conclusions: Better diagnostic tools - such as the liberal use of ultrasound and magnetic resonance imaging - and more accurate pathological definition for ILC type appear to influence the changes in the incidence of ILC in the subgroups of invasive breast cancer.

Original languageEnglish
Pages (from-to)697-700
Number of pages4
JournalIsrael Medical Association Journal
Issue number11
StatePublished - Nov 2010


  • Breast cancer
  • Hormone replacement therapy
  • In vitro fertilization
  • Lobular carcinoma of the breast


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