TY - JOUR
T1 - Factor XIII (FXIII) and angiogenesis
AU - Dardik, R.
AU - Loscalzo, J.
AU - Inbal, Aida
PY - 2006/1
Y1 - 2006/1
N2 - Factor XIII is a plasma transglutaminase that participates in the final stage of the coagulation cascade. Thrombin-activated FXIII (FXIIIa) catalyzes the formation of covalent cross-links between γ-glutamyl and ε-lysyl residues on adjacent fibrin chains in polymerized fibrin to yield the mature clot. In addition to its role in hemostasis, FXIII is known to participate in wound healing and embryo implantation, which are processes involving angiogenesis. In this review, we discuss the role of FXIII in angiogenesis and the molecular mechanisms underlying its proangiogenic effects. The FXIII role in tissue repair and remodeling may at least in part be attributed to its pro-angiogenic activity.
AB - Factor XIII is a plasma transglutaminase that participates in the final stage of the coagulation cascade. Thrombin-activated FXIII (FXIIIa) catalyzes the formation of covalent cross-links between γ-glutamyl and ε-lysyl residues on adjacent fibrin chains in polymerized fibrin to yield the mature clot. In addition to its role in hemostasis, FXIII is known to participate in wound healing and embryo implantation, which are processes involving angiogenesis. In this review, we discuss the role of FXIII in angiogenesis and the molecular mechanisms underlying its proangiogenic effects. The FXIII role in tissue repair and remodeling may at least in part be attributed to its pro-angiogenic activity.
UR - http://www.scopus.com/inward/record.url?scp=33644863719&partnerID=8YFLogxK
U2 - 10.1111/j.1538-7836.2005.01473.x
DO - 10.1111/j.1538-7836.2005.01473.x
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AN - SCOPUS:33644863719
SN - 1538-7933
VL - 4
SP - 19
EP - 25
JO - Journal of Thrombosis and Haemostasis
JF - Journal of Thrombosis and Haemostasis
IS - 1
ER -