A male patient with severe cystic acne was treated with 13‐cis‐retinoic acid in a dosage of 1 mg/kg/day. Early flare‐up of his acne and multiple pyogenic‐like lesions on his face appeared during the second week of isotretinoin treatment. Histologic study of the lesions revealed granulation tissue. Possible etiologies for this phenomenon are discussed.
|Number of pages
|International Journal of Dermatology
|Published - Mar 1992