TY - JOUR
T1 - Extremely high two-photon absorbing graphene oxide for imaging of tumor cells in the second biological window
AU - Pramanik, Avijit
AU - Chavva, Suhash Reddy
AU - Fan, Zhen
AU - Sinha, Sudarson Sekhar
AU - Nellore, Bhanu Priya Viraka
AU - Ray, Paresh Chandra
PY - 2014/6/19
Y1 - 2014/6/19
N2 - Cancer, a life-threatening disease, has become a global pandemic. Targeted tumor imaging using near-infrared (NIR) light is the key to improve the penetration depth and it is highly promising for clinical tumor diagnostics. Driven by this need, in this Letter we have reported aptamer conjugated graphene oxide-based two-photon imaging of breast tumor cells selectively. Reported data indicate that there is an extremely high two-photon absorption from aptamer conjugated graphene oxide (σ2PA = 46890 GM). Experimental data show that two-photon luminescence signal remains almost unchanged even after 2 h of illuminations. Reported results show that S6 RNA aptamers conjugated graphene oxide-based two-photon fluorescence can be used for selective two-photon imaging of SK-BR-3 breast tumor cell in second biological transparency windows using 1100 nm wavelength. Experimental data demonstrate that it is highly capable of distinguishing targeted breast cancer SK-BR-3 cells from other nontargeted MDA-MB-231 breast cancer cells.
AB - Cancer, a life-threatening disease, has become a global pandemic. Targeted tumor imaging using near-infrared (NIR) light is the key to improve the penetration depth and it is highly promising for clinical tumor diagnostics. Driven by this need, in this Letter we have reported aptamer conjugated graphene oxide-based two-photon imaging of breast tumor cells selectively. Reported data indicate that there is an extremely high two-photon absorption from aptamer conjugated graphene oxide (σ2PA = 46890 GM). Experimental data show that two-photon luminescence signal remains almost unchanged even after 2 h of illuminations. Reported results show that S6 RNA aptamers conjugated graphene oxide-based two-photon fluorescence can be used for selective two-photon imaging of SK-BR-3 breast tumor cell in second biological transparency windows using 1100 nm wavelength. Experimental data demonstrate that it is highly capable of distinguishing targeted breast cancer SK-BR-3 cells from other nontargeted MDA-MB-231 breast cancer cells.
KW - graphene oxide
KW - near IR imaging
KW - selective tumor cell imaging
KW - two photon absorption
UR - http://www.scopus.com/inward/record.url?scp=84903178582&partnerID=8YFLogxK
U2 - 10.1021/jz5009856
DO - 10.1021/jz5009856
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AN - SCOPUS:84903178582
SN - 1948-7185
VL - 5
SP - 2150
EP - 2154
JO - Journal of Physical Chemistry Letters
JF - Journal of Physical Chemistry Letters
IS - 12
ER -
