Extracting visual evoked potentials from EEG data recorded during fMRI-guided transcranial magnetic stimulation

Boaz Sadeh, Galit Yovel

Research output: Contribution to journalArticlepeer-review


Transcranial Magnetic Stimulation (TMS) is an effective method for establishing a causal link between a cortical area and cognitive/neurophysiological effects. Specifically, by creating a transient interference with the normal activity of a target region and measuring changes in an electrophysiological signal, we can establish a causal link between the stimulated brain area or network and the electrophysiological signal that we record. If target brain areas are functionally defined with prior fMRI scan, TMS could be used to link the fMRI activations with evoked potentials recorded. However, conducting such experiments presents significant technical challenges given the high amplitude artifacts introduced into the EEG signal by the magnetic pulse, and the difficulty to successfully target areas that were functionally defined by fMRI. Here we describe a methodology for combining these three common tools: TMS, EEG, and fMRI. We explain how to guide the stimulator's coil to the desired target area using anatomical or functional MRI data, how to record EEG during concurrent TMS, how to design an ERP study suitable for EEG-TMS combination and how to extract reliable ERP from the recorded data. We will provide representative results from a previously published study, in which fMRI-guided TMS was used concurrently with EEG to show that the face-selective N1 and the body-selective N1 component of the ERP are associated with distinct neural networks in extrastriate cortex. This method allows us to combine the high spatial resolution of fMRI with the high temporal resolution of TMS and EEG and therefore obtain a comprehensive understanding of the neural basis of various cognitive processes.

Original languageEnglish
Article numbere51063
JournalJournal of Visualized Experiments
Issue number87
StatePublished - 12 May 2014


  • Body perception
  • Combined neuroimaging methods
  • Electroencephalography
  • Event-related potential
  • Evoked potentials
  • Face perception
  • Issue 87
  • Neuroimaging
  • Neuronavigation
  • Neuroscience
  • Transcranial magnetic stimulation
  • Visual perception
  • fMRI


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