TY - JOUR
T1 - Extended family studies for the identification of allogeneic stem cell transplant donors in Jewish and Arabic patients in Israel
AU - Klein, T.
AU - Yaniv, I.
AU - Stein, J.
AU - Narinsky, R.
AU - Finkelstein, Y.
AU - Garty, B. Z.
PY - 2005/2
Y1 - 2005/2
N2 - HLA-identified donors are the best source of allogeneic hematopoietic stem cell transplants, and are available in approximately 40% of cases. If no HLA-identical core family member is found, an extended family search may be performed. The aim of the study was to summarize the 10-year (1990-1999) experience of our tertiary care center with extended family donor search. During this period, 356 patients and 2659 of their family members were tissue-typed; 239 patients were Jewish (67%) and 117 were Arabic (33%). An HLA-identical core-family donor was identified for 168 patients (47%): 95 Jewish (40%) and 73 Arabic (62%) (p < 0.0001); 49 patients (14%) had more than one potential donor. An extended family search (grandmother/grandfather, aunts, uncles, etc.) was performed in 38 of the remaining families, which were found to be consanguineous: five Jewish and 33 Arabic. One HLA match was found in the Jewish families (20%) and 21 in the Arabic families (64%). The odds ratio for an Arabic patient to find a donor in the extended family search was 8.75, as opposed to a Jewish patient. Overall, HLA-matched donors were found by core and extended family search for 53% of the patients. The rate for Arabic patients was 80% and for Jewish patients, 40% (p < 0.001). This difference may be explained by the greater number of siblings and higher rate of consanguinity in the Arabic population. In conclusion, an extended family search for potential HLA-matched donors is worth-while, especially in distinct ethnic populations with high consanguinity, such as Israeli Arabs.
AB - HLA-identified donors are the best source of allogeneic hematopoietic stem cell transplants, and are available in approximately 40% of cases. If no HLA-identical core family member is found, an extended family search may be performed. The aim of the study was to summarize the 10-year (1990-1999) experience of our tertiary care center with extended family donor search. During this period, 356 patients and 2659 of their family members were tissue-typed; 239 patients were Jewish (67%) and 117 were Arabic (33%). An HLA-identical core-family donor was identified for 168 patients (47%): 95 Jewish (40%) and 73 Arabic (62%) (p < 0.0001); 49 patients (14%) had more than one potential donor. An extended family search (grandmother/grandfather, aunts, uncles, etc.) was performed in 38 of the remaining families, which were found to be consanguineous: five Jewish and 33 Arabic. One HLA match was found in the Jewish families (20%) and 21 in the Arabic families (64%). The odds ratio for an Arabic patient to find a donor in the extended family search was 8.75, as opposed to a Jewish patient. Overall, HLA-matched donors were found by core and extended family search for 53% of the patients. The rate for Arabic patients was 80% and for Jewish patients, 40% (p < 0.001). This difference may be explained by the greater number of siblings and higher rate of consanguinity in the Arabic population. In conclusion, an extended family search for potential HLA-matched donors is worth-while, especially in distinct ethnic populations with high consanguinity, such as Israeli Arabs.
KW - Consanguinity
KW - Extended family search
KW - Transplantation
UR - http://www.scopus.com/inward/record.url?scp=13744254607&partnerID=8YFLogxK
U2 - 10.1111/j.1399-3046.2004.00222.x
DO - 10.1111/j.1399-3046.2004.00222.x
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C2 - 15667612
AN - SCOPUS:13744254607
SN - 1397-3142
VL - 9
SP - 52
EP - 55
JO - Pediatric Transplantation
JF - Pediatric Transplantation
IS - 1
ER -