Expression of T cell suppressor activity in the immune response of newborn mice to a T-independent synthetic polypeptide

B. Hardy, E. Mozes

Research output: Contribution to journalArticlepeer-review

Abstract

One and two day old mice responded to the T-independent synthetic polypeptide poly (DTyr.DGlu)-poly(DPro)-poly(DLys) with high antibody production, whereas a dramatic decrease was observed in the immune response of 3 day old injected animals. The presence and expression of suppressor T cells in the 3 day old newborn mice spleens was demonstrated by transferring spleens of 3 day old mice into either thymectomized, irradiated recipients together with bone-marrow cells, or into 1-2 day old newborn recipients. In both cases a significantly lower antibody response was observed in recipients of the 3 day old newborn spleen cells as compared to recipients of the same number of adult spleen cells. No decrease in the antibody levels was detected following inoculation of 3 day old spleen cells after anti-θ-treatment, while enriched T cell populations obtained from nylon wool columns had the same suppressive effect as the whole spleen cell preparations. Thus, the cell expressing the suppressor activity in the newborn spleen is a T cell.

Original languageEnglish
Pages (from-to)757-762
Number of pages6
JournalImmunology
Volume35
Issue number5
StatePublished - 1978
Externally publishedYes

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