Expression of intermediate filaments and stromal proteins in granular cell tumor of the tongue

Dov Ophir, Beatriz Lifschitz-Mercer, Bernard Czernobilsky

Research output: Contribution to journalArticlepeer-review

Abstract

Intermediate filament subunits as well as components of the extracellular matrix, were localized in three cases of granular cell tumor of the tongue. Of the five intermediate filament families, only vimentin was present within the tumor cells. No labeling was obtained with antibodies to cytokeratin, desmin, neurofilaments, and glial filaments; this suggests that this tumor is not derived from epithelium, muscle, neural, or astrocytic origins, respectively. Immunofluorescent staining of the tissue with antibodies to fibronectin and to collagen indicated that the tumor contained low levels of these extracellular matrix proteins. The results suggest the possible use of antibodies to intermediate filaments as histogenetic markers for the clarification of the origin of tumors whose nature cannot be unequivocally determined by conventional histopathologic methods.

Original languageEnglish
Pages (from-to)689-696
Number of pages8
JournalOral Surgery, Oral Medicine, Oral Pathology and Oral Radiology
Volume66
Issue number6
DOIs
StatePublished - Dec 1988
Externally publishedYes

Fingerprint

Dive into the research topics of 'Expression of intermediate filaments and stromal proteins in granular cell tumor of the tongue'. Together they form a unique fingerprint.

Cite this