Expression of interleukin-2 receptors and T cell-macrophage interactions in ascites patients with ovarian cancer

B. Shohat, A. Schoenfeld, T. Segal, H. Levavi, Y. Ovadia

Research output: Contribution to journalArticlepeer-review

Abstract

T-lymphocyte subset markers, as well as their interactions with monocytes and tumor cells, were studied in ascitic abdominal fluid of 8 patients with ovarian carcinoma and one with ascites caused by heart disease. All patients were tested before any chemotherapeutic treatment was initiated. In three patients peripheral blood lymphocytes were also tested. All patients with ovarian carcinoma showed high percentages of T lymphocytes in the peritoneal ascitic fluid while a low percentage was found in the cardiac case. Phenotypic characterization revealed, in 3 out of the 9 patients, T helper/T suppressor lymphocytes (H/S) ratio below 1 in either peripheral blood or the peritoneal cavity. Two of these patients also showed the lowest percentage of monocytes in the peritoneal cavity and died within 2 months of diagnosis. In the other five patients the H/S ratio was above 1.5; they presented with higher percentages of monocytes in the peritoneal cavity. Interleukin-2 expression by monocytes was observed in 3 of them and in two a process of tumor cell-tumor cell emperipolesis with final dissolution of the inner tumor cells was found. A positive correlation between H/S ratio, monocyte percentages and the clinical outcome of patients could be detected.

Original languageEnglish
Pages (from-to)197-200
Number of pages4
JournalCancer Journal
Volume2
Issue number6
StatePublished - 1988
Externally publishedYes

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