Expression of interleukin-11 receptor in CD38-positive cells from patients with multiple myeloma

Alexander Tsimanis, Mordehai Shtalrid, Lev Shvidel, Alexander Kalinkovich, Alain Berrebi, Abraham Klepfish

Research output: Contribution to journalArticlepeer-review

Abstract

Interleukin-11, a cytokine with multiple biological activities, has been shown to stimulate the proliferation and to support the long-term growth of human myeloma cell lines. Despite this, no expression of the interleukin-11α receptor has so far been demonstrated in myeloma cells. We have investigated the expression of interleukin-11α receptor and interleukin-11 at the level of mRNA and protein product in bone marrow mononuclear cells isolated from patients with multiple myeloma using reverse-transcriptase polymerase chain reaction and flow cytometry. The mRNA for interleukin-11α receptor and/or the corresponding protein were identified in 9 of 15 patients with multiple myeloma. In contrast, the interleukin-1 was not detected in any of the patients examined.

Original languageEnglish
Pages (from-to)2315-2319
Number of pages5
JournalLeukemia and Lymphoma
Volume45
Issue number11
DOIs
StatePublished - Nov 2004
Externally publishedYes

Keywords

  • Expression
  • Interleukin-11
  • Interleukin-11α receptor
  • Multiple myeloma

Fingerprint

Dive into the research topics of 'Expression of interleukin-11 receptor in CD38-positive cells from patients with multiple myeloma'. Together they form a unique fingerprint.

Cite this