TY - JOUR
T1 - Expression of interleukin-11 receptor in CD38-positive cells from patients with multiple myeloma
AU - Tsimanis, Alexander
AU - Shtalrid, Mordehai
AU - Shvidel, Lev
AU - Kalinkovich, Alexander
AU - Berrebi, Alain
AU - Klepfish, Abraham
N1 - Funding Information:
This work was supported in part by Ministry of Absorption of Israel.
PY - 2004/11
Y1 - 2004/11
N2 - Interleukin-11, a cytokine with multiple biological activities, has been shown to stimulate the proliferation and to support the long-term growth of human myeloma cell lines. Despite this, no expression of the interleukin-11α receptor has so far been demonstrated in myeloma cells. We have investigated the expression of interleukin-11α receptor and interleukin-11 at the level of mRNA and protein product in bone marrow mononuclear cells isolated from patients with multiple myeloma using reverse-transcriptase polymerase chain reaction and flow cytometry. The mRNA for interleukin-11α receptor and/or the corresponding protein were identified in 9 of 15 patients with multiple myeloma. In contrast, the interleukin-1 was not detected in any of the patients examined.
AB - Interleukin-11, a cytokine with multiple biological activities, has been shown to stimulate the proliferation and to support the long-term growth of human myeloma cell lines. Despite this, no expression of the interleukin-11α receptor has so far been demonstrated in myeloma cells. We have investigated the expression of interleukin-11α receptor and interleukin-11 at the level of mRNA and protein product in bone marrow mononuclear cells isolated from patients with multiple myeloma using reverse-transcriptase polymerase chain reaction and flow cytometry. The mRNA for interleukin-11α receptor and/or the corresponding protein were identified in 9 of 15 patients with multiple myeloma. In contrast, the interleukin-1 was not detected in any of the patients examined.
KW - Expression
KW - Interleukin-11
KW - Interleukin-11α receptor
KW - Multiple myeloma
UR - http://www.scopus.com/inward/record.url?scp=8644289308&partnerID=8YFLogxK
U2 - 10.1080/10428190412331283161
DO - 10.1080/10428190412331283161
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AN - SCOPUS:8644289308
SN - 1042-8194
VL - 45
SP - 2315
EP - 2319
JO - Leukemia and Lymphoma
JF - Leukemia and Lymphoma
IS - 11
ER -
