Expression of human DNA topoisomerase II-α in squamous cell carcinoma of the larynx and its correlation with clinicopathologic variables

Jacob Shvero*, Rumelia Koren, Itzhak Shvili, Eitan Yaniv, Rima Sadov, Tuvia Hadar

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

The aggressiveness of laryngeal squamous cell carcinoma (SCC) is unpredictable. Topoisomerase (Topo) II-α is an essential nuclear enzyme; its expression rises at the end of the S-G2/M phase and drops at completion of mitosis. This study sought to determine if Topo II-α expression can serve as a prognostic factor in laryngeal SCC. Specimens from 56 consecutive patients were immunohistochemically stained for Topo II-α, and the number of positive cells in the areas of highest staining was counted in 3 high-power fields (x400) (Topo II-α index). Differences in the Topo II-α index by the presence or absence of recurrence, tumor stage and grade, and disease course were analyzed statistically. On multivariate Cox regression analysis, the Topo II-α index (>70 or ≤70) (P = .008) and tumor grade (P = .034) independently predicted disease-free survival. These findings suggest that high Topo II-α expression may be a useful indicator of tumor aggressiveness and poor outcome in laryngeal SCC.

Original languageEnglish
Pages (from-to)934-939
Number of pages6
JournalAmerican Journal of Clinical Pathology
Volume130
Issue number6
DOIs
StatePublished - Dec 2008

Keywords

  • Larynx
  • Prognosis
  • Squamous cell carcinoma
  • Topoisomerase II-α index

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