@article{8b0005d3026f4aa3b1e318ae98e2424a,
title = "Expression of genes coding for pS2, c-erbB2, estrogen receptor and the H23 breast tumor-associated antigen. A comparative analysis in breast cancer",
abstract = "Expression of the gene coding for a new breast tumor-associated antigen, H23, was compared to expression of genes coding for pS2, c-erbB2 and estrogen receptor (ER). Comparison involved mRNA expression in normal and malignant breast tissues as well as in non-breast tumors. Results obtained by RNA dot blot and Northern hybridizations showed that expression of the H23 antigen coding gene is a discriminatory marker in human breast cancer. It is expressed in 92% of breast tumors whereas 69%, 62% and 56% of breast tumors demonstrate significant mRNA levels of c-erbB2, ER and pS2, respectively. Non-malignant or normal breast tissue expresses much lower levels of the H23 antigen mRNA. From the comparative analysis presented here it is concluded that the gene coding for H23 antigen furnishes a most useful marker for human breast cancer.",
keywords = "Breast cancer, Breast tumor antigen H23, Breast tumor antigen pS2, Estrogen receptor, Gene expression, Oncogene erbB2",
author = "Zaretsky, {Joseph Z.} and Mordechai Weiss and Ilan Tsarfaty and Mara Hareuveni and Wreschner, {Daniel H.} and Iafa Keydar",
note = "Funding Information: AcknowledgementWs:e thankD r S. Chaitchik,I chilov Hospital,T el Aviv, for providing tissue samples, Moshe Alexandroni for photographic work, G. Hoffnung for the preparation of the manuscripta, ndA lexanderN ezlin for help in the computerg raphics. We are very gratefult o ProfessorP ierre Chambonf or his continued supporta nd fruitful discussionsT. his work wass upportedb y: Simko Chair for BreastC ancer Research,M rs Toby Green, London; Barbara and StevenF riedman,N Y. I.T., M.H. and D.H.W. were the recipientso f EMBO short-termf ellowshipsa nd D.H.W. is the recipient of a Koret FoundationF ellowship,S an Francisco,C A, and a grant from the Israel CancerA ssociation.",
year = "1990",
month = jun,
day = "4",
doi = "10.1016/0014-5793(90)80880-R",
language = "אנגלית",
volume = "265",
pages = "46--50",
journal = "FEBS Letters",
issn = "0014-5793",
publisher = "John Wiley and Sons Inc.",
number = "1-2",
}
