Expression of fibrinolytic genes in atherosclerotic abdominal aortic aneurysm wall. A possible mechanism for aneurysm expansion

Jacob Schneiderman, G. M. Bordin, I. Engelberg, R. Adar, D. Seiffert, T. Thinnes, E. F. Bernstein, R. B. Dilley, D. J. Loskutoff*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


Expansion of atherosclerotic abdominal aortic aneurysm (AAA) has been attributed to remodeling of the extracellular matrix by active proteolysis. We used in situ hybridization to analyze the expression of fibrinolytic genes in aneurysm wall from eight AAA patients. All specimens exhibited specific areas of inflammatory infiltrates with macrophage-like cells expressing urokinase-type plasminogen activator (u-PA) and tissue-type PA (t-PA) mRNA. Type 1 PA inhibitor (PAI-1) mRNA was expressed at the base of the necrotic atheroma of all specimens and also within some of the inflammatory infiltrates where it frequently colocalized in regions containing u-PA and t- PA mRNA expressing cells. However, in these areas, the cellular distribution of the transcripts for t-PA and u-PA extended far beyond the areas of PAI-1 expression. These observations suggest a local ongoing proteolytic process, one which is only partially counteracted by the more restricted expression of PAI-1 mRNA. An abundance of capillaries was also obvious in all inflammatory infiltrates and may reflect local angiogenesis in response to active pericellular fibrinolysis. The increased fibrinolytic capacity in AAA wall may promote angiogenesis and contribute to local proteolytic degradation of the aortic wall leading to physical weakening and active expansion of the aneurysm.

Original languageEnglish
Pages (from-to)639-645
Number of pages7
JournalJournal of Clinical Investigation
Issue number1
StatePublished - 1995
Externally publishedYes


  • abdominal aortic aneurysm
  • angiogenesis
  • in situ hybridization
  • plasminogen activator
  • plasminogen activator inhibitor


Dive into the research topics of 'Expression of fibrinolytic genes in atherosclerotic abdominal aortic aneurysm wall. A possible mechanism for aneurysm expansion'. Together they form a unique fingerprint.

Cite this