Expression of class I histocompatibility antigens in transitional cell carcinoma of the urinary bladder in relation to survival

I. Levin*, T. Klein, J. Goldstein, O. Kuperman, J. Kanetti, B. Klein

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

The expression of class I histocompatibility antigens (HLA) in transitional cell carcinoma of the bladder was studied by the immunoperoxidase technique and correlated with tumor differentiation and survival. Tumors of 33 patients who underwent cystectomy were examined; 57% of the tumors expressed HLA class I antigens. Positive expression was observed in 5 of 6 cases with Grade 1 tumors, 8 of 13 with Grade 2, and 6 of 14 with Grade 3. The 5‐year survival was significantly better in patients with HLA class I‐positive tumors (74%) compared with those with negative tumors (36%, P < 0.05). The expression of HLA class I on tumor cells may serve as a target for the immune response and control the metastatic potential of the tumor. These results suggest that HLA class I expression in bladder carcinoma is a prognostic indicator that should be considered in treatment planning. Cancer 68:2591–2594, 1991.

Original languageEnglish
Pages (from-to)2591-2594
Number of pages4
JournalCancer
Volume68
Issue number12
DOIs
StatePublished - 15 Dec 1991

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