Expression of apoptosis and apoptosis-related proteins in microvessels of human ovarian epithelial tumors

P. Gurevich, H. Ben-Hur, V. Berman, M. Huszar, Y. Tendler, I. Zusman

Research output: Contribution to journalArticlepeer-review

Abstract

We performed an immunohistochemical analysis of apoptosis and the expression of apoptosis-related proteins (ARP) such as Fas and Fas ligand (FasL), bcl-2 and p53 in human ovarian epithelial tumors. Fas and FasL were abundant in endothelial cells of microvessels, and were observed, at times, in the myocytes of small arteries and veins, in parietal or in obstructive thrombi and fibroblasts. Apoptosis was also noticed in the endothelial cells of capillaries and sinuses. The expression of bcl-2 or p53 was rare. We found that the progression of tumor development was accompanied by considerable changes in the microvessels of ovarian tumors. These changes are probably related to the effect of ARP that are expressed by tumor epithelial cells, lymphocytes and macrophages. We suggest that the ARP are released as a result of necrosis of these cells and are taken up by cells of microvessels and by the cellular remnants of blood clots. The effect of tumors on the microvasculature can be regarded as an angiopathy that results in necrosis and hemorrhage within the tumoral tissue and enhances the progression of the malignancy.

Original languageEnglish
Pages (from-to)1335-1338
Number of pages4
JournalAnticancer Research
Volume21
Issue number2 B
StatePublished - 2001
Externally publishedYes

Keywords

  • Apoptosis
  • Endothelial cells
  • Fas and Fas ligand
  • Ovarian epithelial tumors
  • bcl-2
  • p53

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