Expression of a mouse mammary tumor virus cross-reacting antigen on the cell surface of T-47D, a human mammary cell line

Iafa Keydar, Yehuda Ben-Shaul, Amnon Hizi

Research output: Contribution to journalArticlepeer-review

Abstract

An antigen immunologically cross-reacting with the murine mammary virus major glycoprotein (gp52) was found on the cell surfaces of a human breast cancer cell line (T-47D) and its subcloned derivatives. The presence of this antigen was established by various immunological methods: indirect immunoperoxidase technique on live and fixed cells, indirect radioimmunoassay of live cells and immunoscanning electron microscopy. We therefore propose the T-47D cell line and its subclones as an in vitro model system for studying the modulation of expression of this tumor-associated antigen.

Original languageEnglish
Pages (from-to)37-44
Number of pages8
JournalCancer Letters
Volume17
Issue number1
DOIs
StatePublished - Oct 1982

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