Expression of a gene coding for breast tumor-associated antigen in thyroid papillary carcinoma

M. Weiss; J. Zaretsky; R. Zimlichman; N. Smorodinsky; A. S. Dion; I. Keydar; D. H. Wreschner

doi:10.1016/0304-3835(91)90034-F

Expression of a gene coding for breast tumor-associated antigen in thyroid papillary carcinoma

M. Weiss, J. Zaretsky, R. Zimlichman, N. Smorodinsky, A. S. Dion, I. Keydar, D. H. Wreschner

Research output: Contribution to journal › Article › peer-review

Abstract

The expression of the H23 gene, previously shown to be overexpressed in breast cancer tissue, was examined in various thyroid pathologies. Thyroid papillary carcinomas demonstrate significant H23 mRNA levels, whereas benign thyroid pathologies have very low levels of expression. H23 gene expression in thyroid cancer inversely correlated with that of thyroperoxidase and thyroglobulin genes. Immunoblot assays of thyroid cancer tissues revealed overexpression of H23 gene at the protein level as well The data presented indicate that dedifferentiation of thyroid tissue to the malignant state is associated with increased H23 gene expression and suppression of some thyroidal differentiation marker genes.

Original language	English
Pages (from-to)	125-130
Number of pages	6
Journal	Cancer Letters
Volume	58
Issue number	1-2
DOIs	https://doi.org/10.1016/0304-3835(91)90034-F
State	Published - 14 Jun 1991

Keywords

breast cancer
breast tumor antigen
thyroglobulin
thyroid cancer
thyroperoxidase

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10.1016/0304-3835(91)90034-F

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title = "Expression of a gene coding for breast tumor-associated antigen in thyroid papillary carcinoma",

abstract = "The expression of the H23 gene, previously shown to be overexpressed in breast cancer tissue, was examined in various thyroid pathologies. Thyroid papillary carcinomas demonstrate significant H23 mRNA levels, whereas benign thyroid pathologies have very low levels of expression. H23 gene expression in thyroid cancer inversely correlated with that of thyroperoxidase and thyroglobulin genes. Immunoblot assays of thyroid cancer tissues revealed overexpression of H23 gene at the protein level as well The data presented indicate that dedifferentiation of thyroid tissue to the malignant state is associated with increased H23 gene expression and suppression of some thyroidal differentiation marker genes.",

keywords = "breast cancer, breast tumor antigen, thyroglobulin, thyroid cancer, thyroperoxidase",

author = "M. Weiss and J. Zaretsky and R. Zimlichman and N. Smorodinsky and Dion, {A. S.} and I. Keydar and Wreschner, {D. H.}",

note = "Funding Information: This work was supported by the Simko Chair for Breast Cancer Research, Frederic0 Fund Tel Aviv University, grants from the Israel Cancer Association (DHW), Israel Cancer Research Fund (DHW), and the Moise and Frida Eskenasy Institute for Cancer Research (MW and DHW).",

year = "1991",

month = jun,

day = "14",

doi = "10.1016/0304-3835(91)90034-F",

language = "אנגלית",

volume = "58",

pages = "125--130",

journal = "Cancer Letters",

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AU - Weiss, M.

AU - Zaretsky, J.

AU - Zimlichman, R.

AU - Smorodinsky, N.

AU - Dion, A. S.

AU - Keydar, I.

AU - Wreschner, D. H.

N1 - Funding Information: This work was supported by the Simko Chair for Breast Cancer Research, Frederic0 Fund Tel Aviv University, grants from the Israel Cancer Association (DHW), Israel Cancer Research Fund (DHW), and the Moise and Frida Eskenasy Institute for Cancer Research (MW and DHW).

PY - 1991/6/14

Y1 - 1991/6/14

N2 - The expression of the H23 gene, previously shown to be overexpressed in breast cancer tissue, was examined in various thyroid pathologies. Thyroid papillary carcinomas demonstrate significant H23 mRNA levels, whereas benign thyroid pathologies have very low levels of expression. H23 gene expression in thyroid cancer inversely correlated with that of thyroperoxidase and thyroglobulin genes. Immunoblot assays of thyroid cancer tissues revealed overexpression of H23 gene at the protein level as well The data presented indicate that dedifferentiation of thyroid tissue to the malignant state is associated with increased H23 gene expression and suppression of some thyroidal differentiation marker genes.

AB - The expression of the H23 gene, previously shown to be overexpressed in breast cancer tissue, was examined in various thyroid pathologies. Thyroid papillary carcinomas demonstrate significant H23 mRNA levels, whereas benign thyroid pathologies have very low levels of expression. H23 gene expression in thyroid cancer inversely correlated with that of thyroperoxidase and thyroglobulin genes. Immunoblot assays of thyroid cancer tissues revealed overexpression of H23 gene at the protein level as well The data presented indicate that dedifferentiation of thyroid tissue to the malignant state is associated with increased H23 gene expression and suppression of some thyroidal differentiation marker genes.

KW - breast cancer

KW - breast tumor antigen

KW - thyroglobulin

KW - thyroid cancer

KW - thyroperoxidase

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VL - 58

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JO - Cancer Letters

JF - Cancer Letters

SN - 0304-3835

IS - 1-2

ER -

Expression of a gene coding for breast tumor-associated antigen in thyroid papillary carcinoma

Abstract

Keywords

UN SDGs

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