Exposure to Vedolizumab in IBD Pregnant Women Appears of Low Risk for Mother and Neonate: A First Prospective Comparison Study

Ariella Bar-Gil Shitrit; Ami Ben Ya'Acov; Dan Meir Livovsky; Tzufit Cuker; Rivka Farkash; Aviya Hoyda; Tami Granot; Irit Avni-Biron; Adi Lahat; Eran Goldin; Sorina Grisaru-Granovsky

doi:10.14309/ajg.0000000000000186

Exposure to Vedolizumab in IBD Pregnant Women Appears of Low Risk for Mother and Neonate: A First Prospective Comparison Study

Ariella Bar-Gil Shitrit^*, Ami Ben Ya'Acov, Dan Meir Livovsky, Tzufit Cuker, Rivka Farkash, Aviya Hoyda, Tami Granot, Irit Avni-Biron, Adi Lahat, Eran Goldin, Sorina Grisaru-Granovsky

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

54 Scopus citations

Abstract

OBJECTIVES:Despite encouraging data gathered in inflammatory bowel diseases (IBD) patients, Vedolizumabs' (VDZ) safety profile in pregnancy is not established.DESIGN:Data of 330 consecutive pregnancies with IBD was prospectively collected.RESULTS:Women with IBD were treated with: VDZ (n = 24), anti-tumor necrosis factors (n = 82) or conventional therapy (n = 224). Gravidity and parity were similar among the 3 groups. The VDZ group was comprised mostly of Crohn's disease patients who were all not naïve to biological treatment. They had significantly higher conception rates during active disease (P < 0.05), with fewer flares during pregnancy.DISCUSSION:Although further study is needed, VDZ appears of low risk during pregnancy.

Original language	English
Pages (from-to)	1172-1175
Number of pages	4
Journal	American Journal of Gastroenterology
Volume	114
Issue number	7
DOIs	https://doi.org/10.14309/ajg.0000000000000186
State	Published - Jul 2019
Externally published	Yes

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Bar-Gil Shitrit, A., Ben Ya'Acov, A., Livovsky, D. M., Cuker, T., Farkash, R., Hoyda, A., Granot, T., Avni-Biron, I., Lahat, A., Goldin, E., & Grisaru-Granovsky, S. (2019). Exposure to Vedolizumab in IBD Pregnant Women Appears of Low Risk for Mother and Neonate: A First Prospective Comparison Study. American Journal of Gastroenterology, 114(7), 1172-1175. https://doi.org/10.14309/ajg.0000000000000186

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title = "Exposure to Vedolizumab in IBD Pregnant Women Appears of Low Risk for Mother and Neonate: A First Prospective Comparison Study",

abstract = "OBJECTIVES:Despite encouraging data gathered in inflammatory bowel diseases (IBD) patients, Vedolizumabs' (VDZ) safety profile in pregnancy is not established.DESIGN:Data of 330 consecutive pregnancies with IBD was prospectively collected.RESULTS:Women with IBD were treated with: VDZ (n = 24), anti-tumor necrosis factors (n = 82) or conventional therapy (n = 224). Gravidity and parity were similar among the 3 groups. The VDZ group was comprised mostly of Crohn's disease patients who were all not na{\"i}ve to biological treatment. They had significantly higher conception rates during active disease (P < 0.05), with fewer flares during pregnancy.DISCUSSION:Although further study is needed, VDZ appears of low risk during pregnancy.",

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Bar-Gil Shitrit, A, Ben Ya'Acov, A, Livovsky, DM, Cuker, T, Farkash, R, Hoyda, A, Granot, T, Avni-Biron, I, Lahat, A, Goldin, E & Grisaru-Granovsky, S 2019, 'Exposure to Vedolizumab in IBD Pregnant Women Appears of Low Risk for Mother and Neonate: A First Prospective Comparison Study', American Journal of Gastroenterology, vol. 114, no. 7, pp. 1172-1175. https://doi.org/10.14309/ajg.0000000000000186

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T1 - Exposure to Vedolizumab in IBD Pregnant Women Appears of Low Risk for Mother and Neonate

T2 - A First Prospective Comparison Study

AU - Bar-Gil Shitrit, Ariella

AU - Ben Ya'Acov, Ami

AU - Livovsky, Dan Meir

AU - Cuker, Tzufit

AU - Farkash, Rivka

AU - Hoyda, Aviya

AU - Granot, Tami

AU - Avni-Biron, Irit

AU - Lahat, Adi

AU - Goldin, Eran

AU - Grisaru-Granovsky, Sorina

PY - 2019/7

Y1 - 2019/7

N2 - OBJECTIVES:Despite encouraging data gathered in inflammatory bowel diseases (IBD) patients, Vedolizumabs' (VDZ) safety profile in pregnancy is not established.DESIGN:Data of 330 consecutive pregnancies with IBD was prospectively collected.RESULTS:Women with IBD were treated with: VDZ (n = 24), anti-tumor necrosis factors (n = 82) or conventional therapy (n = 224). Gravidity and parity were similar among the 3 groups. The VDZ group was comprised mostly of Crohn's disease patients who were all not naïve to biological treatment. They had significantly higher conception rates during active disease (P < 0.05), with fewer flares during pregnancy.DISCUSSION:Although further study is needed, VDZ appears of low risk during pregnancy.

AB - OBJECTIVES:Despite encouraging data gathered in inflammatory bowel diseases (IBD) patients, Vedolizumabs' (VDZ) safety profile in pregnancy is not established.DESIGN:Data of 330 consecutive pregnancies with IBD was prospectively collected.RESULTS:Women with IBD were treated with: VDZ (n = 24), anti-tumor necrosis factors (n = 82) or conventional therapy (n = 224). Gravidity and parity were similar among the 3 groups. The VDZ group was comprised mostly of Crohn's disease patients who were all not naïve to biological treatment. They had significantly higher conception rates during active disease (P < 0.05), with fewer flares during pregnancy.DISCUSSION:Although further study is needed, VDZ appears of low risk during pregnancy.

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JF - American Journal of Gastroenterology

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Exposure to Vedolizumab in IBD Pregnant Women Appears of Low Risk for Mother and Neonate: A First Prospective Comparison Study

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