@article{6206651156eb47c48d1b25eed449da6e,
title = "Exploring the role of hepcidin, an antimicrobial and iron regulatory peptide, in increased iron absorption in β-thalassemia",
abstract = "To develop new treatments for β-thalassemia, it is essential to identify the genes involved in the relevant pathophysiological processes. Iron metabolism in thalassemia mice being investigated, focusing on the expression of a gene called hepcidin (Hamp), which is expressed in the liver and whose product (Hamp) is secreted into the bloodstream. In mice, iron overload leads to overespression of Hamp, while Hamp-knockout mice suffer from hemochromatosis. The aim of this study is to investigate Hamp in the mouse model of β-thalassemia and to address the potential gene transfer of Hamp to prevent abnormal iron absorption.",
keywords = "Gene expression, Hamp, Iron overload, Lentivirus, β-thalassemia",
author = "Laura Breda and Sara Gardenghi and Ella Guy and Rachmilewitz, {Eliezer A.} and Orly Weizer-Stern and Konstantin Adamsky and Ninette Amariglio and Gideon Rechavi and Giardina, {Patricia J.} and Grady, {Robert W.} and Stefano Rivella",
year = "2005",
doi = "10.1196/annals.1345.069",
language = "אנגלית",
volume = "1054",
pages = "417--422",
journal = "Annals of the New York Academy of Sciences",
issn = "0077-8923",
publisher = "John Wiley and Sons Inc.",
}