Exploring the nuclear lamina in health and pathology using C. elegans

Chayki Charar, Sally Metsuyanim-Cohen, Yosef Gruenbaum, Daniel Z. Bar*

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

Abstract

The eukaryotic genome inside the nucleus is enveloped by two membranes, the Outer Nuclear Membrane (ONM) and the Inner Nuclear Membrane (INM). Tethered to the INM is the nuclear lamina, a fibrillar network composed of lamins—the nuclear intermediate filaments, and membrane associated proteins. The nuclear lamina interacts with several nuclear structures, including chromatin. As most nuclear functions, including regulation of gene expression, chromosome segregation and duplication as well as nuclear structure, are highly conserved in metazoans, the Caenorhabditis elegans nematode serves as a powerful model organism to study nuclear processes and architecture. This translucent organism can easily be observed under a microscope as a live embryo, larvae and even adult. Here we will review the data on nuclear lamina composition and functions gathered from studies using C. elegans model organisms: We will discuss genome spatial organization and its contribution to gene expression. We will review both the interaction between the cytoplasm and the nucleus and mechanotransduction mechanism. Finally, we will discuss disease causing mutation in nuclear lamins, including the use of this animal model in diseases research.

Original languageEnglish
Title of host publicationNematode Models of Development and Disease
EditorsSophie Jarriault, Benjamin Podbilewicz
PublisherAcademic Press Inc.
Pages91-110
Number of pages20
ISBN (Print)9780128161777
DOIs
StatePublished - Jan 2021

Publication series

NameCurrent Topics in Developmental Biology
Volume144
ISSN (Print)0070-2153

Keywords

  • LEM domain proteins
  • LINC complex
  • Lamin
  • Laminopathies
  • Nuclear Lamina
  • Nuclear envelope

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