TY - JOUR
T1 - Exploring hepatitis A dynamics in Israel, 2019–2022
AU - Gozlan, Yael
AU - Zuckerman, Neta S.
AU - Yizchaki, Mayyan
AU - Rich, Rivka
AU - Bar-Or, Itay
AU - Mor, Orna
N1 - Publisher Copyright:
© 2024 Elsevier B.V.
PY - 2024/12/10
Y1 - 2024/12/10
N2 - Background: Continuous monitoring of Hepatitis A Virus (HAV) may assist in identifying local outbreaks. The advent of the COVID-19 pandemic, which affected the circulation of numerous pathogens, may have also impacted the scope of HAV infections. Aim: To investigate the incidence and environmental dissemination of HAV between 2019 and 2022 in Israel, a country with an anti-HAV vaccination program. Methods: HAV RT-PCR analysis was performed for all HAV cases and for 280 sewage samples collected in 2019–2022. Available amplified HAV fragments from clinical (n = 107) and sewage (n = 27) were also assessed by genotyping and phylogenetic analysis. Results: In 2019–2022, 158 individuals and 12.9 % (36/280) of sewage samples were HAV-RNA positive. Median age was 30 years (IQR 20.5–44); approximately half (51.9 %, 82/158) were males. Almost all patients (98.4 %, 124/126) were not vaccinated. Highest numbers were identified in 2019 (84 cases and 30 %, 21/71, positive sewage samples). In 2020, when three COVID-19 related lockdowns were implemented, 24 cases and 4.3 % (3/69) sewage samples were HAV-RNA positive. The number of HAV-RNA positive cases and positive sewage samples remained low in 2021–2022 (31 and 19 cases, 13.2 %, 9/68 and 4.2 %, 3/72 positive sewage samples, respectively). Sub-genotype IB dominated (90.7 %, 97/107 of cases and 81.5 %, 22/27 of sewage samples), and phylogenetic analysis of HAV samples demonstrated small transmission clusters of sequences from Jews, Bedouin Arabs and foreign workers. Sub-genotype IA was identified in 8.4 % (9/107) of cases and in 18.5 % (5/27) of sewage samples. Conclusion: Combined clinical and environmental surveillance is optimal for monitoring HAV. In 2020, the circulation of HAV decreased, possibly following COVD-19 health restrictions. In subsequent years, the incidence remained low. Adults in risk-groups for HAV infection should be vaccinated to minimize HAV circulation.
AB - Background: Continuous monitoring of Hepatitis A Virus (HAV) may assist in identifying local outbreaks. The advent of the COVID-19 pandemic, which affected the circulation of numerous pathogens, may have also impacted the scope of HAV infections. Aim: To investigate the incidence and environmental dissemination of HAV between 2019 and 2022 in Israel, a country with an anti-HAV vaccination program. Methods: HAV RT-PCR analysis was performed for all HAV cases and for 280 sewage samples collected in 2019–2022. Available amplified HAV fragments from clinical (n = 107) and sewage (n = 27) were also assessed by genotyping and phylogenetic analysis. Results: In 2019–2022, 158 individuals and 12.9 % (36/280) of sewage samples were HAV-RNA positive. Median age was 30 years (IQR 20.5–44); approximately half (51.9 %, 82/158) were males. Almost all patients (98.4 %, 124/126) were not vaccinated. Highest numbers were identified in 2019 (84 cases and 30 %, 21/71, positive sewage samples). In 2020, when three COVID-19 related lockdowns were implemented, 24 cases and 4.3 % (3/69) sewage samples were HAV-RNA positive. The number of HAV-RNA positive cases and positive sewage samples remained low in 2021–2022 (31 and 19 cases, 13.2 %, 9/68 and 4.2 %, 3/72 positive sewage samples, respectively). Sub-genotype IB dominated (90.7 %, 97/107 of cases and 81.5 %, 22/27 of sewage samples), and phylogenetic analysis of HAV samples demonstrated small transmission clusters of sequences from Jews, Bedouin Arabs and foreign workers. Sub-genotype IA was identified in 8.4 % (9/107) of cases and in 18.5 % (5/27) of sewage samples. Conclusion: Combined clinical and environmental surveillance is optimal for monitoring HAV. In 2020, the circulation of HAV decreased, possibly following COVD-19 health restrictions. In subsequent years, the incidence remained low. Adults in risk-groups for HAV infection should be vaccinated to minimize HAV circulation.
KW - COVID-19
KW - Hepatitis A Virus
KW - Surveillance
KW - Wastewater
UR - http://www.scopus.com/inward/record.url?scp=85207245647&partnerID=8YFLogxK
U2 - 10.1016/j.scitotenv.2024.176861
DO - 10.1016/j.scitotenv.2024.176861
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C2 - 39437928
AN - SCOPUS:85207245647
SN - 0048-9697
VL - 955
JO - Science of the Total Environment
JF - Science of the Total Environment
M1 - 176861
ER -