TY - JOUR
T1 - Exploring Helical Peptides and Foldamers for the Design of Metal Helix Frameworks
T2 - Current Trends and Future Perspectives
AU - Bajpayee, Nikhil
AU - Vijayakanth, Thangavel
AU - Rencus-Lazar, Sigal
AU - Dasgupta, Sneha
AU - Desai, Aamod V.
AU - Jain, Rahul
AU - Gazit, Ehud
AU - Misra, Rajkumar
N1 - Publisher Copyright:
© 2022 Wiley-VCH GmbH.
PY - 2023/2/1
Y1 - 2023/2/1
N2 - Flexible and biocompatible metal peptide frameworks (MPFs) derived from short and ultra-short peptides have been explored for the storage of greenhouse gases, molecular recognition, and chiral transformations. In addition to short flexible peptides, peptides with specifically folded conformations have recently been utilized to fabricate a variety of metal helix frameworks (MHFs). The secondary structures of the peptides govern the structure-assembly relationship and thereby control the formation of three-dimensional (3D)-MHFs. Particularly, the hierarchical structural organization of peptide-based MHFs has not yet been discussed in detail. Here, we describe the recent progress of metal-driven folded peptide assembly to construct 3D porous structures for use in future energy storage, chiral recognition, and biomedical applications, which could be envisioned as an alternative to the conventional metal-organic frameworks (MOFs).
AB - Flexible and biocompatible metal peptide frameworks (MPFs) derived from short and ultra-short peptides have been explored for the storage of greenhouse gases, molecular recognition, and chiral transformations. In addition to short flexible peptides, peptides with specifically folded conformations have recently been utilized to fabricate a variety of metal helix frameworks (MHFs). The secondary structures of the peptides govern the structure-assembly relationship and thereby control the formation of three-dimensional (3D)-MHFs. Particularly, the hierarchical structural organization of peptide-based MHFs has not yet been discussed in detail. Here, we describe the recent progress of metal-driven folded peptide assembly to construct 3D porous structures for use in future energy storage, chiral recognition, and biomedical applications, which could be envisioned as an alternative to the conventional metal-organic frameworks (MOFs).
KW - Biocompatibility
KW - Foldamers
KW - Helical Peptides
KW - Metal-Helix Frameworks
KW - Porous Structures
UR - http://www.scopus.com/inward/record.url?scp=85143885373&partnerID=8YFLogxK
U2 - 10.1002/anie.202214583
DO - 10.1002/anie.202214583
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C2 - 36434750
AN - SCOPUS:85143885373
SN - 1433-7851
VL - 62
JO - Angewandte Chemie - International Edition
JF - Angewandte Chemie - International Edition
IS - 6
M1 - e202214583
ER -