Experimental VT: A new porcine model of infarct-related reentrant VT

Elad Anter, Andrew L. Wit, Mark E. Josephson

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

Abstract

A number of laboratory models using experimental animals have been developed in an attempt to study the ventricular arrhythmias that occur during the healing or the healed phase of infarction. The most established animal models for ventricular tachycardia (VT) in the healing or healed infarct are canine models. Dog models of coronary occlusion most commonly include selective occlusion of the proximal left anterior descending (LAD) artery and/or circumflex. These usually exhibit large and transmural infarcts. The authors have recently developed a chronic infarct model in swine that resembles human infarction with reentrant VTs. This model of LAD artery occlusion results in a large anteroseptal scar with predominant subendocardial myocardial fiber preservation as in human infarction. The authors utilized the model of infarction with reentrant VT in conjunction with a high-resolution mapping technology to study the electrophysiological characteristics of post-infarction reentrant VT.

Original languageEnglish
Title of host publicationCardiac Mapping
Publisherwiley
Pages398-407
Number of pages10
ISBN (Electronic)9781119152637
ISBN (Print)9781119152590
DOIs
StatePublished - 5 Apr 2019
Externally publishedYes

Keywords

  • Canine models
  • Chronic infarct model
  • Infarct-related reentrant ventricular arrhythmias
  • Mapping technology
  • Proximal left anterior descending artery

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