Experimental vaccination with candida albicans ribosomes in cyclophosphamide-treated animals

Esther Segal*, Hana Sandovsky-Losica

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


A study was carried out to determine whether protection against experimental systemic candidiasis can be induced by vaccination with Candida albicans ribosomes in animals compromised by cyclophosphamide (CY) treatment. ICR mice treated with CY showed a reduction in the number of leukocytes and a decrease in spleen and body weights. CY-treated mice were more susceptible to intraperitoneal (IP) or intravenous (IV) challenge with live C. albicans than the untreated animals. Vaccination of CY-treated mice with C. albicans ribosomes, with or without addition of incomplete Freund's adjuvant, led to a partial protection against a lethal IP or IV challenge with live yeasts. These results indicate the possible effectiveness of ribosomal vaccination in protecting the compromised host against experimental candidiasis.

Original languageEnglish
Pages (from-to)267-273
Number of pages7
JournalMedical Mycology
Issue number4
StatePublished - 1981


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