Experimental tools to study molecular recognition within the nanoparticle corona

Markita P. Landry, Sebastian Kruss, Justin T. Nelson, Gili Bisker, Nicole M. Iverson, Nigel F. Reuel, Michael S. Strano*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


Advancements in optical nanosensor development have enabled the design of sensors using synthetic molecular recognition elements through a recently developed method called Corona Phase Molecular Recognition (CoPhMoRe). The synthetic sensors resulting from these design principles are highly selective for specific analytes, and demonstrate remarkable stability for use under a variety of conditions. An essential element of nanosensor development hinges on the ability to understand the interface between nanoparticles and the associated corona phase surrounding the nanosensor, an environment outside of the range of traditional characterization tools, such as NMR. This review discusses the need for new strategies and instrumentation to study the nanoparticle corona, operating in both in vitro and in vivo environments. Approaches to instrumentation must have the capacity to concurrently monitor nanosensor operation and the molecular changes in the corona phase. A detailed overview of new tools for the understanding of CoPhMoRe mechanisms is provided for future applications.

Original languageEnglish
Pages (from-to)16196-16211
Number of pages16
Issue number9
StatePublished - 2 Sep 2014
Externally publishedYes


  • Carbon nanotubes
  • Corona phase
  • Fluorescence
  • Molecular recognition
  • Neurotransmitters
  • Optical sensors
  • Single-molecule microscopy


Dive into the research topics of 'Experimental tools to study molecular recognition within the nanoparticle corona'. Together they form a unique fingerprint.

Cite this