Experimental investigation of the influence of the aortic stiffness on hemodynamics in the ascending aorta

Utku Gülan*, Beat Lüthi, Markus Holzner, Alex Liberzon, Arkady Tsinober, Wolfgang Kinzelbach

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

27 Scopus citations

Abstract

A three-dimensional (3-D) pulsatile aortic flow in a human ascending aorta is studied to investigate the effect of the aortic stiffness on the flow field and turbulent fluctuating velocities in the ascending aorta. A nonintrusive optical measurement technique, 3-D particle tracking velocimetry (3D-PTV), has been applied to anatomically accurate phantoms under clinically realistic conditions. A compliant silicon phantom was used to mimic the healthy aorta, and a rigid model was used to imitate the pathological case that appears in aortas for example as a result of aging. The realistic models are transparent which allows optical access to the investigation domain, and the index of refraction was matched to avoid optical distortions. Our results revealed that the aortic stiffness leads to an increase in systolic velocity and a decrease in the Windkessel effect, which is associated with the diastolic blood pressure. Furthermore, we found that the turbulent kinetic energy is about an order of magnitude higher for the rigid aorta, that is, an increase in aortic stiffness increases the magnitude of turbulent fluctuating velocities. The spatial distribution of the flow velocity showed that the flow is more organized and coherent spiraling patterns develop for the compliant aorta which helps to dampen the influence of disturbed flow. Finally,we observed higher Lagrangian acceleration and hence higher instantaneous forces acting on blood particles in the stiff casewhich implies that aging and hence arterial stiffening provokes distinctive alterations in blood flow, and these alterationsmay cause pathological symptoms in the cardiovascular system.

Original languageEnglish
Article number6813616
Pages (from-to)1775-1780
Number of pages6
JournalIEEE Journal of Biomedical and Health Informatics
Volume18
Issue number6
DOIs
StatePublished - 1 Nov 2014

Keywords

  • Aortic flow
  • Aortic stiffness
  • Ascending aorta
  • Lagrangian flow field
  • Three-dimensional particle tracking velocimetry (3D-PTV)
  • Windkessel effect

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