@article{c94d781afda74baf85bd1868cf8c85d9,
title = "Experimental definition of a clustered regularly interspaced short palindromic duplicon in escherichia coli",
abstract = "We analyzed sequences of newly inserted repeats in an Escherichia coli CRISPR (clustered regularly interspaced short palindromic repeats) array in vivo and showed that a base previously thought to belong to the repeat is actually derived from a protospacer. Based on further experimental results, we propose to use the term duplicon for a repeated sequence in a CRISPR array that serves as a template for a new duplicon. Our findings suggest the possibility of redrawing the borders between repeats, spacers, and protospacer adjacent motifs.",
keywords = "CRISPR adaptation, DNA template, bacteriophage, defense mechanism",
author = "Goren, {Moran G.} and Ido Yosef and Oren Auster and Udi Qimron",
note = "Funding Information: This work was supported by the Israel Science Foundation ( 611/10 ) and a Marie Curie International Reintegration Grant ( PIRG-GA-2009-256340 ).",
year = "2012",
month = oct,
day = "12",
doi = "10.1016/j.jmb.2012.06.037",
language = "אנגלית",
volume = "423",
pages = "14--16",
journal = "Journal of Molecular Biology",
issn = "0022-2836",
publisher = "Academic Press",
number = "1",
}