TY - JOUR
T1 - Experimental and clinical studies of 5-fluorocytosine activity in Candida ocular infections
T2 - I. in vitro activity of 5-fluorocytosine on candida species isolated from ocular infections
AU - Segal, E.
AU - Romano, A.
AU - Eylan, E.
AU - Stein, R.
PY - 1975
Y1 - 1975
N2 - In vitro sensitivity to 5-Fluorocytosine (5-FC) of 35 Candida strains (14 C. albicans, 10 C. tropicalis, 5 C. parapsilosis, 2 C. guilliermondii, 2 C. krusei, 2 C. pseudotropicalis), isolated from the eyes of patients suffering from various external ocular inflammations who had not been treated with 5-FC, was tested and compared to that of standard Candida species. The minimal inhibitory concentration (MIC) and minimal fungicidal concentration (MFC) of 5-FC for the strains isolated from ocular infections ranged from 0.06 to 1.95 μg/ml and from 0.24 to 7.81 μg/ml, respectively, indicating that no primary resistant strains to 5-FC were found in this series.
AB - In vitro sensitivity to 5-Fluorocytosine (5-FC) of 35 Candida strains (14 C. albicans, 10 C. tropicalis, 5 C. parapsilosis, 2 C. guilliermondii, 2 C. krusei, 2 C. pseudotropicalis), isolated from the eyes of patients suffering from various external ocular inflammations who had not been treated with 5-FC, was tested and compared to that of standard Candida species. The minimal inhibitory concentration (MIC) and minimal fungicidal concentration (MFC) of 5-FC for the strains isolated from ocular infections ranged from 0.06 to 1.95 μg/ml and from 0.24 to 7.81 μg/ml, respectively, indicating that no primary resistant strains to 5-FC were found in this series.
KW - 5-Fluorocytosine sensitivity
KW - Candida ocular infections
UR - http://www.scopus.com/inward/record.url?scp=0016753184&partnerID=8YFLogxK
U2 - 10.1159/000221880
DO - 10.1159/000221880
M3 - ???researchoutput.researchoutputtypes.contributiontojournal.article???
AN - SCOPUS:0016753184
SN - 0009-3157
VL - 21
SP - 358
EP - 366
JO - Chemotherapy
JF - Chemotherapy
IS - 6
ER -