Experimental and clinical studies of 5-fluorocytosine activity in Candida ocular infections: I. in vitro activity of 5-fluorocytosine on candida species isolated from ocular infections

E. Segal, A. Romano, E. Eylan, R. Stein

Research output: Contribution to journalArticlepeer-review

Abstract

In vitro sensitivity to 5-Fluorocytosine (5-FC) of 35 Candida strains (14 C. albicans, 10 C. tropicalis, 5 C. parapsilosis, 2 C. guilliermondii, 2 C. krusei, 2 C. pseudotropicalis), isolated from the eyes of patients suffering from various external ocular inflammations who had not been treated with 5-FC, was tested and compared to that of standard Candida species. The minimal inhibitory concentration (MIC) and minimal fungicidal concentration (MFC) of 5-FC for the strains isolated from ocular infections ranged from 0.06 to 1.95 μg/ml and from 0.24 to 7.81 μg/ml, respectively, indicating that no primary resistant strains to 5-FC were found in this series.

Original languageEnglish
Pages (from-to)358-366
Number of pages9
JournalChemotherapy
Volume21
Issue number6
DOIs
StatePublished - 1975

Keywords

  • 5-Fluorocytosine sensitivity
  • Candida ocular infections

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