Experimental allergic encephalomyelitis: A misleading model of multiple sclerosis

Subramaniam Sriram, Israel Steiner

Research output: Contribution to journalReview articlepeer-review

Abstract

Despite many years of intensive research, multiple sclerosis (MS) defies understanding and treatment remains suboptimal. The prevailing hypothesis is that MS is immune mediated and that experimental allergic encephalomyelitis (EAE) is a suitable model to elucidate pathogenesis and devise therapy. This review examines critically the validity that EAE is an adequate and useful animal model of MS and finds credible evidence lacking. EAE represents more a model of acute central nervous system inflammation than the counterpart of MS. We propose to reconsider die utilization of EAE, especially when this model is used to define therapy. This will also force us to examine MS without the restraints imposed by EAE, as to what it is, rather than what it looks like.

Original languageEnglish
Pages (from-to)939-945
Number of pages7
JournalAnnals of Neurology
Volume58
Issue number6
DOIs
StatePublished - Dec 2005
Externally publishedYes

Fingerprint

Dive into the research topics of 'Experimental allergic encephalomyelitis: A misleading model of multiple sclerosis'. Together they form a unique fingerprint.

Cite this