TY - JOUR
T1 - Expanding the boundaries of embryonic stem cells
AU - Ben-David, Uri
AU - Kopper, Oded
AU - Benvenisty, Nissim
N1 - Funding Information:
The authors thank Dr. Daniel Ronen for critically reading this manuscript and Tamar Golan-Lev for her assistance with the graphical design of the figures. N.B. is the Herbert Cohn Chair in Cancer Research. This research was partially supported by the Legacy Heritage Biomedical Science Partnership Program of the Israel Science Foundation (grant 943/09), the Centers of Excellence Legacy Heritage Biomedical Science Partnership (grant 1801/10), and the Juvenile Diabetes Research Foundation (grant 1-2011-555).
PY - 2012/6/14
Y1 - 2012/6/14
N2 - The boundaries of embryonic stem cell (ESC) research have extended considerably in recent years in several important ways. Alongside a deeper understanding of the pluripotent state, ESCs have been successfully integrated into various fields, such as genomics, epigenetics, and disease modeling. Significant progress in cell fate control has pushed directed differentiation and tissue engineering further than ever before and promoted clinical trials. The geographical distribution of research activity has also expanded, especially for human ESCs. This review outlines these developments and future challenges that remain.
AB - The boundaries of embryonic stem cell (ESC) research have extended considerably in recent years in several important ways. Alongside a deeper understanding of the pluripotent state, ESCs have been successfully integrated into various fields, such as genomics, epigenetics, and disease modeling. Significant progress in cell fate control has pushed directed differentiation and tissue engineering further than ever before and promoted clinical trials. The geographical distribution of research activity has also expanded, especially for human ESCs. This review outlines these developments and future challenges that remain.
UR - https://www.scopus.com/pages/publications/84862514386
U2 - 10.1016/j.stem.2012.05.003
DO - 10.1016/j.stem.2012.05.003
M3 - ???researchoutput.researchoutputtypes.contributiontojournal.systematicreview???
C2 - 22704506
AN - SCOPUS:84862514386
SN - 1934-5909
VL - 10
SP - 666
EP - 677
JO - Cell Stem Cell
JF - Cell Stem Cell
IS - 6
ER -