Exhaustive non-synonymous variants functionality prediction enables high resolution characterization of the neurofibromin architecture

Keyphrases

• Neurofibromatosis Type I 100%
• Neurofibromatosis Type 1 (NF-1) 100%
• Neurofibromin 100%
• Synonymous Variant 100%
• High-resolution Characterization 100%
• Functionality Prediction 100%
• Pathogenicity 33%
• Codon 22%
• Cell Differentiation 11%
• Exon 11%
• Prediction Value 11%
• Truncating Variant 11%
• Functional Prediction 11%
• Splice Site 11%
• Cell Proliferation 11%
• Tumor Suppressor 11%
• Novel Functions 11%
• Missense 11%
• Prediction Model 11%
• Machine Learning Techniques 11%
• Area under the ROC Curve 11%
• Gain-of-function mutation 11%
• Site Variation 11%
• Ras Signaling 11%
• Functional Domain 11%
• Disease-associated 11%
• Novel Domains 11%
• Disease Variants 11%
• NsSNPs 11%
• Armadillo 11%
• Inferential Statistics 11%
• Biomedical Research Centres 11%

Biochemistry, Genetics and Molecular Biology

• Codon 100%
• Exon 50%
• Missense 50%
• Single-Nucleotide Polymorphism 50%
• Tumor Suppressor Protein 50%
• Cell Proliferation 50%
• Cellular Differentiation 50%
• Armadillo 50%
• Neurofibromin 1 50%