Excretion of dipyrone metabolites in human breast milk

E. Zylber-Katz; N. Linder; L. Granit; M. Levy

doi:10.1007/BF00541545

Excretion of dipyrone metabolites in human breast milk

E. Zylber-Katz^*, N. Linder, L. Granit, M. Levy

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

Abstract

Breast milk and plasma levels of dipyrone metabolites in 8 mothers given a single oral dose of the drug were determined by HPLC. Four metabolites were demonstrated by the analytical method: 4-methylaminoantipyrine (MAA), 4-aminoantipyrine (AA), 4-formylaminoantipyrine (FAA) and 4-acetylaminoantipyrine (AAA). A good correlation was found between the plasma and milk concentrations of the metabolites. The mean (±SD) milk to plasma concentration ratios were: MAA=1.37±0.28, AA=1.15±0.40, FAA=1.03±0.09, AAA=0.97±0.24. The disposition pattern of the dipyrone metabolites in milk was studied in two mothers. None of the metabolites was detectable 48 h after drug administration.

Original language	English
Pages (from-to)	359-361
Number of pages	3
Journal	European Journal of Clinical Pharmacology
Volume	30
Issue number	3
DOIs	https://doi.org/10.1007/BF00541545
State	Published - May 1986
Externally published	Yes

Keywords

dipyrone
excretion in milk
metabolites

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10.1007/BF00541545

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title = "Excretion of dipyrone metabolites in human breast milk",

abstract = "Breast milk and plasma levels of dipyrone metabolites in 8 mothers given a single oral dose of the drug were determined by HPLC. Four metabolites were demonstrated by the analytical method: 4-methylaminoantipyrine (MAA), 4-aminoantipyrine (AA), 4-formylaminoantipyrine (FAA) and 4-acetylaminoantipyrine (AAA). A good correlation was found between the plasma and milk concentrations of the metabolites. The mean (±SD) milk to plasma concentration ratios were: MAA=1.37±0.28, AA=1.15±0.40, FAA=1.03±0.09, AAA=0.97±0.24. The disposition pattern of the dipyrone metabolites in milk was studied in two mothers. None of the metabolites was detectable 48 h after drug administration.",

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T1 - Excretion of dipyrone metabolites in human breast milk

AU - Zylber-Katz, E.

AU - Linder, N.

AU - Granit, L.

AU - Levy, M.

PY - 1986/5

Y1 - 1986/5

N2 - Breast milk and plasma levels of dipyrone metabolites in 8 mothers given a single oral dose of the drug were determined by HPLC. Four metabolites were demonstrated by the analytical method: 4-methylaminoantipyrine (MAA), 4-aminoantipyrine (AA), 4-formylaminoantipyrine (FAA) and 4-acetylaminoantipyrine (AAA). A good correlation was found between the plasma and milk concentrations of the metabolites. The mean (±SD) milk to plasma concentration ratios were: MAA=1.37±0.28, AA=1.15±0.40, FAA=1.03±0.09, AAA=0.97±0.24. The disposition pattern of the dipyrone metabolites in milk was studied in two mothers. None of the metabolites was detectable 48 h after drug administration.

AB - Breast milk and plasma levels of dipyrone metabolites in 8 mothers given a single oral dose of the drug were determined by HPLC. Four metabolites were demonstrated by the analytical method: 4-methylaminoantipyrine (MAA), 4-aminoantipyrine (AA), 4-formylaminoantipyrine (FAA) and 4-acetylaminoantipyrine (AAA). A good correlation was found between the plasma and milk concentrations of the metabolites. The mean (±SD) milk to plasma concentration ratios were: MAA=1.37±0.28, AA=1.15±0.40, FAA=1.03±0.09, AAA=0.97±0.24. The disposition pattern of the dipyrone metabolites in milk was studied in two mothers. None of the metabolites was detectable 48 h after drug administration.

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KW - excretion in milk

KW - metabolites

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Excretion of dipyrone metabolites in human breast milk

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