Excretion of dipyrone metabolites in human breast milk

E. Zylber-Katz*, N. Linder, L. Granit, M. Levy

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


Breast milk and plasma levels of dipyrone metabolites in 8 mothers given a single oral dose of the drug were determined by HPLC. Four metabolites were demonstrated by the analytical method: 4-methylaminoantipyrine (MAA), 4-aminoantipyrine (AA), 4-formylaminoantipyrine (FAA) and 4-acetylaminoantipyrine (AAA). A good correlation was found between the plasma and milk concentrations of the metabolites. The mean (±SD) milk to plasma concentration ratios were: MAA=1.37±0.28, AA=1.15±0.40, FAA=1.03±0.09, AAA=0.97±0.24. The disposition pattern of the dipyrone metabolites in milk was studied in two mothers. None of the metabolites was detectable 48 h after drug administration.

Original languageEnglish
Pages (from-to)359-361
Number of pages3
JournalEuropean Journal of Clinical Pharmacology
Issue number3
StatePublished - May 1986
Externally publishedYes


  • dipyrone
  • excretion in milk
  • metabolites


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