Excision of nucleoside analogs from DNA by p53 protein, a potential cellular mechanism of resistance to inhibitors of human immunodeficiency virus type 1 reverse transcriptase

Mary Bakhanashvili, Elena Novitsky, Ethan Rubinstein, Itzchak Levy, Galia Rahav

Research output: Contribution to journalArticlepeer-review

Abstract

We investigated the ability of p53 in cytoplasm to excise nucleoside analogs (NAs). A decrease in incorporation of NAs by human immunodeficiency virus type 1 reverse transcriptase and their excision from DNA by p53, provided by the cytoplasmic fraction of LCC2 cells, suggest that p53 in cytoplasm may act as an external proofreader for NA incorporation.

Original languageEnglish
Pages (from-to)1576-1579
Number of pages4
JournalAntimicrobial Agents and Chemotherapy
Volume49
Issue number4
DOIs
StatePublished - Apr 2005
Externally publishedYes

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