TY - JOUR
T1 - Excess mortality and morbidity among small-for-gestational-age premature infants
T2 - A population-based study
AU - Regev, Rivka H.
AU - Lusky, Ayala
AU - Dolfin, Tzipora
AU - Litmanovitz, Ita
AU - Arnon, Shmuel
AU - Reichman, Brian
N1 - Funding Information:
The Israel National Very Low Birth-weight infant database is partially funded by the Israel Center for Disease Control and the Ministry of Health.
PY - 2003/8/1
Y1 - 2003/8/1
N2 - Objective: We examined the effect of intrauterine growth restriction on mortality and morbidity in the Israel cohort of very low birth weight premature infants. Methods: The study population included 2764 singleton very low birth weight infants without congenital malformations born from 24 to 31 weeks of gestation during 1995 to 1999. Four hundred six (15%) were born small for gestational age (SGA). The effect of SGA on death, bronchopulmonary dysplasia, and retinopathy of prematurity was assessed using multiple logistic regression analysis. Results: After adjustment for perinatal risk factor. SGA infants had a 4.52-fold risk for death (95% CI, 3.24-6.33), a 3.42-fold risk for bronchopulmonary dysplasia (95% CI, 2.29-5.13), and a 2.06-fold risk for grade 3 to 4 retinopathy of prematurity (95% CI. 1.15-3.66). Conclusions: SGA premature infants had an increased risk for death, and major morbidity among survivors was increased.
AB - Objective: We examined the effect of intrauterine growth restriction on mortality and morbidity in the Israel cohort of very low birth weight premature infants. Methods: The study population included 2764 singleton very low birth weight infants without congenital malformations born from 24 to 31 weeks of gestation during 1995 to 1999. Four hundred six (15%) were born small for gestational age (SGA). The effect of SGA on death, bronchopulmonary dysplasia, and retinopathy of prematurity was assessed using multiple logistic regression analysis. Results: After adjustment for perinatal risk factor. SGA infants had a 4.52-fold risk for death (95% CI, 3.24-6.33), a 3.42-fold risk for bronchopulmonary dysplasia (95% CI, 2.29-5.13), and a 2.06-fold risk for grade 3 to 4 retinopathy of prematurity (95% CI. 1.15-3.66). Conclusions: SGA premature infants had an increased risk for death, and major morbidity among survivors was increased.
UR - http://www.scopus.com/inward/record.url?scp=0041331646&partnerID=8YFLogxK
U2 - 10.1067/S0022-3476(03)00181-1
DO - 10.1067/S0022-3476(03)00181-1
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AN - SCOPUS:0041331646
SN - 0022-3476
VL - 143
SP - 186
EP - 191
JO - Journal of Pediatrics
JF - Journal of Pediatrics
IS - 2
ER -