@article{c4d724d3fce240a685e3f7c342430c96,
title = "Examining Several Strategies for the Chemical Synthesis of Phosphorylated Histone H3 Reveals the Effectiveness of the Convergent Approach",
abstract = "Phosphorylation of Ser57 of the histone H3 was suggested to interact with the acetylated Lys56 of histone H3 and possibly affect DNA replication. Yet the exact role of Ser57 remains unknown due to difficulties in obtaining phosphorylated H3 at Ser57. Herein, we present the challenges and the solutions in the first total chemical synthesis of phosphorylated and unphosphorylated histone H3 analogues utilizing hydrazide-based native chemical ligation approach coupled with palladium-mediated thiazolidine decaging chemistry to provide each one of these analogues in highly efficient manner. We envision this synthesis would set the ground to elucidating the role of the phosphorylation and its cross-talk with acetylation mark in H3 in the DNA damage response.",
keywords = "Chemical protein synthesis, Convergent synthesis, Histone 3, Palladium, Phosphorylation",
author = "Muhammad Jbara and Maity, {Suman Kumar} and Ashraf Brik",
note = "Publisher Copyright: {\textcopyright} 2019 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim",
year = "2020",
month = jun,
day = "8",
doi = "10.1002/ejoc.201900257",
language = "אנגלית",
volume = "2020",
pages = "3128--3132",
journal = "European Journal of Organic Chemistry",
issn = "1434-193X",
publisher = "Wiley-VCH Verlag",
number = "21",
}