TY - JOUR
T1 - Examination stress, platelet peripheral benzodiazepine binding sites, and plasma hormone levels
AU - Karp, Leon
AU - Weizman, Abraham
AU - Tyano, Sam
AU - Gavish, Moshe
N1 - Funding Information:
This study was supported by a grant from the Israel Ministry of Health. We thank Zehava Tanne for her technical assistance and Ruth Singer for typing the manuscript.
PY - 1989
Y1 - 1989
N2 - The maximal binding capacity (Bmax) and the equilibrium dissociation constant (KD)values for [3H]PK 11195 binding to peripheral benzodiazepine binding sites were measured in the platelets of subjects immediately after examination stress and 10 days later, as well as in unstressed controls. Increased (52%; p < 0.05) Bmax, but unaltered KD, values were observed immediately after the stress as compared to the controls. Ten days after the stress, a slight decrease (15%) in the number of peripheral benzodiazepine binding sites was observed, but their values remained higher (29%) in comparison to unstressed controls. Levels of plasma stress hormones (cortisol, growth hormone, and prolactin) did not differ in the stressed subjects from those of the controls.
AB - The maximal binding capacity (Bmax) and the equilibrium dissociation constant (KD)values for [3H]PK 11195 binding to peripheral benzodiazepine binding sites were measured in the platelets of subjects immediately after examination stress and 10 days later, as well as in unstressed controls. Increased (52%; p < 0.05) Bmax, but unaltered KD, values were observed immediately after the stress as compared to the controls. Ten days after the stress, a slight decrease (15%) in the number of peripheral benzodiazepine binding sites was observed, but their values remained higher (29%) in comparison to unstressed controls. Levels of plasma stress hormones (cortisol, growth hormone, and prolactin) did not differ in the stressed subjects from those of the controls.
UR - http://www.scopus.com/inward/record.url?scp=0024383739&partnerID=8YFLogxK
U2 - 10.1016/0024-3205(89)90334-2
DO - 10.1016/0024-3205(89)90334-2
M3 - ???researchoutput.researchoutputtypes.contributiontojournal.article???
AN - SCOPUS:0024383739
SN - 0024-3205
VL - 44
SP - 1077
EP - 1082
JO - Life Sciences
JF - Life Sciences
IS - 16
ER -