Examination of the therapeutic potential of mouse oral mucosa stem cells in a wound-healing diabetic mice model

Shiri Kuperman; Ram Efraty; Ina Arie; Arkadi Rahmanov; Marina Rahmanov Gavrielov; Matityahau Noff; Ron Fishel; Sandu Pitaru

doi:10.3390/ijerph17134854

Examination of the therapeutic potential of mouse oral mucosa stem cells in a wound-healing diabetic mice model

Shiri Kuperman^*, Ram Efraty, Ina Arie, Arkadi Rahmanov, Marina Rahmanov Gavrielov, Matityahau Noff, Ron Fishel, Sandu Pitaru

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

Abstract

Diabetic wounds’ delayed healing response is still considered a major therapeutic challenge. Stem cells and derived cellular products have been an active field of research for novel therapies referred to as regenerative medicine. It has recently been shown that human oral mucosa stem cells (hOMSCs) are a readily accessible source for obtaining large quantities of stem cells. This study evaluates the potential of mouse oral mucosa stem cells (mOMSCs) to enhance wound healing in a diabetic (db/db) mouse model by morphological and histological analysis. We show that mOMSCs-treated wounds displayed a significantly faster wound-healing response (p ≤ 0.0001), featuring faster re-epithelialization and a larger area of granulation tissue (p ≤ 0.05). Taken together, these results suggest that oral mucosa stem cells might have therapeutic potential in diabetic wound healing.

Original language	English
Article number	4854
Pages (from-to)	1-10
Number of pages	10
Journal	International Journal of Environmental Research and Public Health
Volume	17
Issue number	13
DOIs	https://doi.org/10.3390/ijerph17134854
State	Published - 1 Jul 2020

Keywords

Diabetic mice model
Diabetic wound healing model
Oral stem cells
Wound healing

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.3390/ijerph17134854

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title = "Examination of the therapeutic potential of mouse oral mucosa stem cells in a wound-healing diabetic mice model",

abstract = "Diabetic wounds{\textquoteright} delayed healing response is still considered a major therapeutic challenge. Stem cells and derived cellular products have been an active field of research for novel therapies referred to as regenerative medicine. It has recently been shown that human oral mucosa stem cells (hOMSCs) are a readily accessible source for obtaining large quantities of stem cells. This study evaluates the potential of mouse oral mucosa stem cells (mOMSCs) to enhance wound healing in a diabetic (db/db) mouse model by morphological and histological analysis. We show that mOMSCs-treated wounds displayed a significantly faster wound-healing response (p ≤ 0.0001), featuring faster re-epithelialization and a larger area of granulation tissue (p ≤ 0.05). Taken together, these results suggest that oral mucosa stem cells might have therapeutic potential in diabetic wound healing.",

keywords = "Diabetic mice model, Diabetic wound healing model, Oral stem cells, Wound healing",

author = "Shiri Kuperman and Ram Efraty and Ina Arie and Arkadi Rahmanov and Gavrielov, {Marina Rahmanov} and Matityahau Noff and Ron Fishel and Sandu Pitaru",

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AU - Kuperman, Shiri

AU - Efraty, Ram

AU - Arie, Ina

AU - Rahmanov, Arkadi

AU - Gavrielov, Marina Rahmanov

AU - Noff, Matityahau

AU - Fishel, Ron

AU - Pitaru, Sandu

PY - 2020/7/1

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N2 - Diabetic wounds’ delayed healing response is still considered a major therapeutic challenge. Stem cells and derived cellular products have been an active field of research for novel therapies referred to as regenerative medicine. It has recently been shown that human oral mucosa stem cells (hOMSCs) are a readily accessible source for obtaining large quantities of stem cells. This study evaluates the potential of mouse oral mucosa stem cells (mOMSCs) to enhance wound healing in a diabetic (db/db) mouse model by morphological and histological analysis. We show that mOMSCs-treated wounds displayed a significantly faster wound-healing response (p ≤ 0.0001), featuring faster re-epithelialization and a larger area of granulation tissue (p ≤ 0.05). Taken together, these results suggest that oral mucosa stem cells might have therapeutic potential in diabetic wound healing.

AB - Diabetic wounds’ delayed healing response is still considered a major therapeutic challenge. Stem cells and derived cellular products have been an active field of research for novel therapies referred to as regenerative medicine. It has recently been shown that human oral mucosa stem cells (hOMSCs) are a readily accessible source for obtaining large quantities of stem cells. This study evaluates the potential of mouse oral mucosa stem cells (mOMSCs) to enhance wound healing in a diabetic (db/db) mouse model by morphological and histological analysis. We show that mOMSCs-treated wounds displayed a significantly faster wound-healing response (p ≤ 0.0001), featuring faster re-epithelialization and a larger area of granulation tissue (p ≤ 0.05). Taken together, these results suggest that oral mucosa stem cells might have therapeutic potential in diabetic wound healing.

KW - Diabetic mice model

KW - Diabetic wound healing model

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Examination of the therapeutic potential of mouse oral mucosa stem cells in a wound-healing diabetic mice model

Abstract

Keywords

UN SDGs

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