@article{dd0085d7b840424a98bf151b8e4ecba5,
title = "Ex Vivo Expanded 3D Human Kidney Spheres Engraft Long Term and Repair Chronic Renal Injury in Mice",
abstract = "Human kidney cells quickly degenerate in culture, precluding them as a source for cell therapy for chronic kidney disease (CKD). Herein, Harari-Steinberg et al. show that upon culturing as 3D nephrospheres, human kidney cells regain their epithelial phenotype and acquire in vivo tissue-forming and reparative properties in a CKD mouse model.",
keywords = "3D culture, 5/6 nephrectomy, antifibrotic effect, autologous treatment, in vivo differentiation, kidney regeneration, kidney stem cells, mouse CKD model, nephrospheres, renal epithelial differentiation",
author = "Orit Harari-Steinberg and Dorit Omer and Yehudit Gnatek and Oren Pleniceanu and Sanja Goldberg and Osnat Cohen-Zontag and Sara Pri-Chen and Itamar Kanter and {Ben Haim}, Nissim and Eli Becker and Roi Ankawa and Yaron Fuchs and Tomer Kalisky and Zohar Dotan and Benjamin Dekel",
note = "Publisher Copyright: {\textcopyright} 2019 The Authors",
year = "2020",
month = jan,
day = "21",
doi = "10.1016/j.celrep.2019.12.047",
language = "אנגלית",
volume = "30",
pages = "852--869.e4",
journal = "Cell Reports",
issn = "2211-1247",
publisher = "Cell Press",
number = "3",
}
