Evolution of isopenicillin N synthase genes may have involved horizontal gene transfer

Giddy Landan, Gerald Cohen, Yair Aharonowitz, Yuval Shuali, Dan Graur*, Dov Shiffman

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

The isopenicillin N synthase genes from three fungal species, three Gram-positive species, and one Gram-negative bacterial species share an unusually high sequence similarity. A phylogentic analysis was earned out to determine which type of evolutionary scenario best accounts for this similarity. The most plausible scenario is one in which a horizontal gene-transfer event, from the prokaryotes to the eukaryotes. occurred at a time close to the divergence between the Gram-positive and the Gram-negative bacteria.

Original languageEnglish
Pages (from-to)399-406
Number of pages8
JournalMolecular Biology and Evolution
Volume7
Issue number5
StatePublished - 1990

Keywords

  • Horizontal gene transfer
  • Isopenicillin n synthase

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