Evidence that apomorphine and (+)-amphetamine produce different types of circling in rats

A. R. Cools, W. Scheenen, D. Eilam, I. Golani

Research output: Contribution to journalArticlepeer-review

Abstract

Apomorphine and (+)-amphetamine are known to produce circling in naive rats. Frame by frame analysis of videotape recordings of the behaviour of Wistar rats treated with a subcutaneous injection of apomorphine (1.1 mg/kg; n=8) or (+)-amphetamine (0.5 and 1.0 mg/kg; n=8 and n=8) was used to study this behaviour in more detail. In line with previously reported studies, apomorphine was found to change the functioning of hindlimb stepping. In contrast, (+)-amphetamine was found to change the functioning of forelimb stepping. These data imply that apomorphine and (+)-amphetamine produce their drug-specific circling via different substrates within the brain.

Original languageEnglish
Pages (from-to)111-116
Number of pages6
JournalBehavioural Brain Research
Volume34
Issue number1-2
DOIs
StatePublished - 1 Aug 1989

Keywords

  • (+)-Amphetamine
  • Apomorphine
  • Circling
  • Rat
  • Stepping

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